Automation and globalisation are expected to negatively affect up to 20% of the UK workforce after 2030, according to Centre for Cities.
Local and national leaders are being urged to act, as around 3.6 million jobs face replacement by automation across the country - with northern and midlands cities most affected.
Mansfield, Sunderland and Wakefield are most at risk with 29% of jobs in each city likely to be lost, according to the Cities Outlook 2018 report, published today.
Andrew Carter, chief executive of Centre for Cities said: “Automation and globalisation will bring huge opportunities to increase prosperity and jobs, but there is also a real risk that many people and places will lose out.
“The time to act is now – national and local leaders need to ensure that people in cities across the North and Midlands can share in the benefits these changes could offer.”
According to the report the cities most likely to be affected were also among those to have voted most strongly for Brexit.
Mr Carter called on government leaders to reform the education system to give children the skills they need for a changing labour market and better retraining programs in areas with higher rates of job losses.
“In an evermore divided country, it’s increasingly clear that a one-size-fits-all approach from central government is inadequate to address the myriad issues that different places face,” he said.
The job roles most likely to face replacement are for those working in retail, customer services and warehouses.