Housing and planning minister Gavin Barwell was among a handful of ministers to lose his seat on a night Theresa May and the Conservatives failed to pick up enough seats to form a majority government.
Parliament will be hung, raising doubts over the short and long-term future of a number of key policy areas including Brexit negotiations and adult social care.
On a bruising night for the Tories, who had been hoping to make major gains, Mr Barwell failed to defend his slim 165-vote majority in Croydon Central.
Social care minister David Mowat lost his Warrington South seat, as did the minister for vulnerable children Edward Timpson (Crewe and Nantwich). Public health minister Nicola Blackwood also failed to successfully defend her Oxford West and Abingdon constituency for the Conservatives.
Communities secretary Sajid Javid retained his Bromsgrove seat, while local government minister Marcus Jones (Nuneaton) and Northern Powerhouse minister Andrew Percy (Brigg and Goole) also held on. Mr Percy’s predecessor in that role James Wharton, who moved from DCLG to become a minister in the Department for International Development, was another victim.
With only four constituencies left to declare, the Conservatives with 315 seats are short of the 326 needed to win. Labour has 261 seats, the Liberal Democrats 10.